Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

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作者： Steven H,Liang ^[1] ; Jinshan Michael,Chen ^[2] ; Marc D,Normandin ^[1] ; Jeanne S,Chang ^[2] ; George C,Chang ^[2] ; Christine K,Taylor ^[2] ; Patrick,Trapa ^[3] ; Mark S,Plummer ^[2] ; Kimberly S,Para ^[2] ; Edward L,Conn ^[2] ; Lori,Lopresti-Morrow ^[2] ; Lorraine F,Lanyon ^[2] ; James M,Cook ^[2] ; Karl E G,Richter ^[2] ; Charlie E,Nolan ^[2] ; Joel B,Schachter ^[2] ; Fouad,Janat ^[2] ; Ye,Che ^[2] ; Veerabahu,Shanmugasundaram ^[2] ; Bruce A,Lefker ^[3] ; Bradley E,Enerson ^[2] ; Elijahu,Livni ^[1] ; Lu,Wang ^[1] ; Nicolas J,Guehl ^[1] ; Debasis,Patnaik ^[4] ; Florence F,Wagner ^[5] ; Roy,Perlis ^[5] ; Edward B,Holson ^[4] ; Stephen J,Haggarty ^[5] ; Georges,El Fakhri ^[4] ; Ravi G,Kurumbail ^[1] ; Neil,Vasdev ^[6]

作者单位： Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA. ^[1] Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA. ^[2] Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA, 02139, USA. ^[3] Departments of Neurology & Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA. ^[4] Stanley Center for Psychiatric Research, Broad Institute, 415 Main Street, Cambridge, MA, o2142, USA. ^[5] Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA. ravi.g.kurumbail@pfizer.com. ^[6] Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA. vasdev.neil@mgh.harvard.edu. ^[7]

关键词 Alzheimer's disease glycogen synthase kinase-3 phosphorylation positron emission tomography tau proteins