Spheronization mechanism of pharmaceutical material crystals processed by extremely high shearing force using a mechanical powder processor.

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第一作者： Keita,Kondo

第一单位： Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan. Electronic address: kondok@meijo-u.ac.jp.

作者： Keita,Kondo ^[1] ; Keisuke,Kido ^[2] ; Toshiyuki,Niwa ^[2]

作者单位： Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan. Electronic address: kondok@meijo-u.ac.jp. ^[1] Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan. ^[2]

关键词 Layering granulation Mechanical powder processor Mechanical spheronization technique Particle shape modification Particle strength Pharmaceutical material Powder agglomeration Powder cohesiveness Spherical crystal

主题词化学, 药物(Chemistry, Pharmaceutical);显微镜检查, 电子, 扫描(Microscopy, Electron, Scanning);药用制剂(Pharmaceutical Preparations);粉剂(Powders)

DOI 10.1016/j.ejpb.2016.06.021

PMID 27368746

发布时间 2017-03-10

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