Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.-论文-万方医学网

作者： Deborah L,Smith ^[1] ; Jennifer E,Davoren ^[2] ; Jeremy R,Edgerton ^[2] ; John T,Lazzaro ^[2] ; Che-Wah,Lee ^[2] ; Sarah,Neal ^[2] ; Lei,Zhang ^[2] ; Sarah,Grimwood ^[2]

作者单位： Neuroscience and Pain Research Unit (D.L.S., J.R.E., S.N., S.G.) and Worldwide Medicinal Chemistry (J.E.D., L.Z.), Pfizer Inc., Cambridge, Massachusetts; Primary Pharmacology Group (J.T.L.) and Worldwide Medicinal Chemistry (C.-W.L.), Pfizer Inc., Groton, Connecticut Deborah.L.Smith@Pfizer.com. ^[1] Neuroscience and Pain Research Unit (D.L.S., J.R.E., S.N., S.G.) and Worldwide Medicinal Chemistry (J.E.D., L.Z.), Pfizer Inc., Cambridge, Massachusetts; Primary Pharmacology Group (J.T.L.) and Worldwide Medicinal Chemistry (C.-W.L.), Pfizer Inc., Groton, Connecticut. ^[2]

主题词乙酰胆碱(Acetylcholine);别构调节(Allosteric Regulation);动物(Animals);放射自显影术(Autoradiography);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);电生理学现象(Electrophysiological Phenomena);荧光计(Fluorometry);HEK293细胞(HEK293 Cells);海马(Hippocampus);人类(Humans);异吲哚类(Isoindoles);动力学(Kinetics);男(雄)性(Male);膜(Membranes);N-甲基东莨菪碱(N-Methylscopolamine);正电子发射断层显像术(Positron-Emission Tomography);吡啶类(Pyridines);放射配体测定(Radioligand Assay);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 毒蕈碱M1(Receptor, Muscarinic M1)

DOI 10.1124/mol.116.104737

PMID 27382013

发布时间 2025-02-13

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Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.

Molecular pharmacology

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Molecular pharmacology

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Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.

Molecular pharmacology

相似文献

Molecular pharmacology

相关期刊

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