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首页> Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine> Cytotoxicity of withasteroids: withametelin induces cell cycle arrest at G2/M phase and mitochondria-mediated apoptosis in non-small cell lung cancer A549 cells.

Cytotoxicity of withasteroids: withametelin induces cell cycle arrest at G2/M phase and mitochondria-mediated apoptosis in non-small cell lung cancer A549 cells.

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作者： Poorna Chandra,Rao ^[1] ; Sajeli,Begum ^[2] ; Mohammad Ali Farboodniay,Jahromi ^[3] ; Zahra Hosseini,Jahromi ^[4] ; Saketh,Sriram ^[5] ; Mahendra,Sahai ^[6]

作者单位： Department of Pharmacy, Birla Institute of Technology and Science - Pilani Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad, Telangana State, 500078, India. ^[1] Department of Pharmacy, Birla Institute of Technology and Science - Pilani Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad, Telangana State, 500078, India. sajeli@hyderabad.bits-pilani.ac.in. ^[2] Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. ^[3] Biology Division, Shahed 15 Education Center, Shiraz, Iran. ^[4] Biological Research Department, Incozen Therapeutics Pvt Ltd, Alexandria Knowledge Park, Turakapally, Hyderabad, Telangana State, India. ^[5] Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India. ^[6]

关键词 Apoptosis Cytotoxicity Lung cancer ROS Withametelin Withasteroids

主题词细胞凋亡(Apoptosis);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);内酯类(Lactones);肺肿瘤(Lung Neoplasms);膜电位, 线粒体(Membrane Potential, Mitochondrial);线粒体(Mitochondria);植物甾醇类(Phytosterols);活性氧(Reactive Oxygen Species)

DOI 10.1007/s13277-016-5128-5

PMID 27382976

发布时间 2018-11-13

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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Tumour biology

2016年37卷9期

12579-12587页

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