Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.

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第一作者： Maojia,Xu

第一单位： Regenerative Medicine Institute, National University of Ireland Galway, Galway, Ireland.

作者： Maojia,Xu ^[1] ; Eva-Lena,Stattin ^[2] ; Georgina,Shaw ^[1] ; Dick,Heinegård ^[3] ; Gareth,Sullivan ^[4] ; Ian,Wilmut ^[5] ; Alan,Colman ^[6] ; Patrik,Önnerfjord ^[3] ; Areej,Khabut ^[3] ; Anders,Aspberg ^[3] ; Peter,Dockery ^[7] ; Timothy,Hardingham ^[8] ; Mary,Murphy ^[1] ; Frank,Barry ^[9]

作者单位： Regenerative Medicine Institute, National University of Ireland Galway, Galway, Ireland. ^[1] Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. ^[2] Department of Clinical Sciences, Rheumatology, and Molecular Skeletal Biology, Lund University, Lund, Sweden. ^[3] Norwegian Center for Stem Cell Research, Oslo, Norway. ^[4] Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom. ^[5] A*STAR Institute of Medical Biology, Singapore. ^[6] Anatomy, School of Medicine, National University of Ireland Galway, Galway, Ireland. ^[7] Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences University of Manchester, Manchester, United Kingdom. ^[8] Regenerative Medicine Institute, National University of Ireland Galway, Galway, Ireland frank.barry@nuigalway.ie. ^[9]

关键词 Aggrecan mutation Cellular pathology Endoplasmic reticulum stress Familial osteochondritis dissecans Induced pluripotent stem cells Mesenchymal stromal cells Osteoarthritis Stem cell disease models