Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.

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作者： Tiago,Rodrigues ^[1] ; Florian,Sieglitz ^[2] ; Víctor J,Somovilla ^[3] ; Pedro M S D,Cal ^[4] ; Antony,Galione ^[2] ; Francisco,Corzana ^[5] ; Gonçalo J L,Bernardes ^[6]

作者单位： Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. tiago.rodrigues@medicina.ulisboa.pt. ^[1] Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. ^[2] Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de la Rioja, 26006, Logroño, Spain. ^[3] Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK. ^[4] Department of Pharmacology, University of Oxford, Mansfield Road, OX1 3QT, Oxford, UK. ^[5] Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de la Rioja, 26006, Logroño, Spain. francisco.corzana@unirioja.es. ^[6] Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. gbernardes@medicina.ulisboa.pt, gb453@cam.ac.uk. ^[7] Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK. gbernardes@medicina.ulisboa.pt, gb453@cam.ac.uk. ^[8]

关键词 chemical biology molecular recognition natural products target prediction voltage-gated calcium channels

主题词钙通道阻滞药(Calcium Channel Blockers);钙通道, L型(Calcium Channels, L-Type);人类(Humans);模型, 分子(Models, Molecular);分子结构(Molecular Structure);叶下珠属(Phyllanthus);倍半萜类, 愈创木烷(Sesquiterpenes, Guaiane)

DOI 10.1002/anie.201604336

PMID 27391219

发布时间 2023-11-11

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