In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity.

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作者： Emese Irma,Ágoston ^[1] ; Tamás,Micsik ^[2] ; Balázs,Ács ^[3] ; Krisztina,Fekete ^[1] ; Oszkár,Hahn ^[1] ; Zsolt,Baranyai ^[1] ; Kristóf,Dede ^[4] ; György,Bodoky ^[5] ; Attila,Bursics ^[4] ; Janina,Kulka ^[3] ; Tibor,Krenács ^[2] ; Balázs,Győrffy ^[6] ; László,Harsányi ^[7] ; A Marcell,Szász ^[8]

作者单位： Department of Surgery, Semmelweis University, 78 Üllői út, Budapest, 1082, Hungary. ^[1] Department of Pathology and Experimental Cancer Research, Semmelweis University, 26 Üllői út, Budapest, 1085, Hungary. ^[2] Department of Pathology, Semmelweis University, 93 Üllői út, Budapest, 1091, Hungary. ^[3] Department of Surgery and Oncological Surgery, Uzsoki Teaching Hospital, 196 Róna utca, Budapest, 1145, Hungary. ^[4] Department of Oncology, Szent István Hospital, 1 Nagyvárad tér, Budapest, 1097, Hungary. ^[5] MTA-TTK Lendület Cancer Biomarker Research Group, Magyar tudósok körútja 2, Budapest, 1117, Hungary. ^[6] Department of Surgery, Semmelweis University, 78 Üllői út, Budapest, 1082, Hungary. hl@seb1.sote.hu. ^[7] Department of Pathology, Semmelweis University, 93 Üllői út, Budapest, 1091, Hungary. cac@korb2.sote.hu. ^[8] MTA-TTK Lendület Cancer Biomarker Research Group, Magyar tudósok körútja 2, Budapest, 1117, Hungary. cac@korb2.sote.hu. ^[9]

关键词 Colorectal cancer Immunohistochemistry Intratumoral heterogeneity PTEN Predictive marker Prognostic marker Protein expression