Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expression of hypoxia-inducible factor-1α via mTOR/4E-BP1 signaling pathways.
第一作者:
Juan,Ma
第一单位:
Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China.
作者:
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞周期蛋白质类(Cell Cycle Proteins);结直肠肿瘤(Colorectal Neoplasms);自由基清除剂(Free Radical Scavengers);HCT116细胞(HCT116 Cells);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);单萜类(Monoterpenes);磷蛋白类(Phosphoproteins);蛋白质生物合成(Protein Biosynthesis);活性氧(Reactive Oxygen Species);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);肿瘤负荷(Tumor Burden);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.intimp.2016.06.034
PMID
27394002
发布时间
2021-12-04
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