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Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis.

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第一作者： Gui-Bai,Liang

第一单位： Merck Research Laboratories, Department of Discovery Chemistry, Rahway, NJ 07065, USA. Electronic address: liang_gui-bai@wuxiapptec.com.

作者： Gui-Bai,Liang ^[1] ; Changyou,Zhou ^[2] ; Xianghong,Huo ^[2] ; Hank,Wang ^[2] ; Xuelin,Yang ^[2] ; Shaoqiang,Huang ^[2] ; Haisheng,Wang ^[2] ; Hilary,Wilkinson ^[3] ; Lusong,Luo ^[2] ; Wei,Tang ^[2] ; David,Sutton ^[2] ; Hong,Li ^[2] ; Dennis,Zaller ^[3] ; Peter T,Meinke ^[4]

作者单位： Merck Research Laboratories, Department of Discovery Chemistry, Rahway, NJ 07065, USA. Electronic address: liang_gui-bai@wuxiapptec.com. ^[1] Bioduro, a PPD Company, Bld E. No. 29, Life Science Park Road, Changping District, Beijing 102206, China. ^[2] Merck Research Laboratories, Department of Bone, Respiratory, Immunology and Endocrinology, Rahway, NJ 07065, USA. ^[3] Merck Research Laboratories, Department of Discovery Chemistry, Rahway, NJ 07065, USA. ^[4]

关键词 CaSR-antagonist Calcium-sensing receptor (CaSR)Cyclopropane carboxylic acid Osteoporosis Parathyroid hormone (PTH)