The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.

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作者： Theresa A,Reno ^[1] ; Sun-Wing,Tong ^[2] ; Jun,Wu ^[3] ; John M,Fidler ^[4] ; Rebecca,Nelson ^[5] ; Jae Y,Kim ^[6] ; Dan J,Raz ^[6]

作者单位： Division of Thoracic Surgery, City of Hope Medical Center, 1500 E. Duarte Rd., Duarte, CA, 91010, USA. treno@coh.org. ^[1] Department of Pathology, City of Hope Medical Center, Duarte, CA, USA. ^[2] Division of Comparative Medicine, Beckman Research Institute, City of Hope Medical Center, Duarte, CA, USA. ^[3] MyeloRx LLC, Vallejo, CA, USA. ^[4] Department of Biostatistics, City of Hope Medical Center, Duarte, CA, USA. ^[5] Division of Thoracic Surgery, City of Hope Medical Center, 1500 E. Duarte Rd., Duarte, CA, 91010, USA. ^[6]

关键词 Lung cancer MRx102 Metastasis Triptolide Wnt

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);卡铂(Carboplatin);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);二萜类(Diterpenes);药物评价, 临床前(Drug Evaluation, Preclinical);药物疗法, 联合(Drug Therapy, Combination);环氧化合物(Epoxy Compounds);人类(Humans);肺肿瘤(Lung Neoplasms);小鼠(Mice);肿瘤侵润(Neoplasm Invasiveness);菲类(Phenanthrenes);阻遏蛋白质类(Repressor Proteins);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1186/s12885-016-2487-7

PMID 27400883

发布时间 2018-11-13

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BMC cancer

2016年16卷

439页

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The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.

BMC cancer

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BMC cancer

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The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.

BMC cancer

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BMC cancer

相关期刊

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