Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

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第一作者： Junzeng,Fu

第一单位： Department of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. j.fu@lacdr.leidenuniv.nl.

作者： Junzeng,Fu ^[1] ; Johannes C,Schoeman ^[2] ; Amy C,Harms ^[3] ; Herman A,van Wietmarschen ^[4] ; Rob J,Vreeken ^[3] ; Ruud,Berger ^[4] ; Bart V J,Cuppen ^[5] ; Floris P J G,Lafeber ^[6] ; Jan,van der Greef ^[3] ; Thomas,Hankemeier ^[4]

作者单位： Department of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. j.fu@lacdr.leidenuniv.nl. ^[1] Sino-Dutch Center for Preventive and Personalized Medicine, P.O. Box 360, 3700 AJ, Zeist, The Netherlands. j.fu@lacdr.leidenuniv.nl. ^[2] Department of Analytical Biosciences, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. ^[3] Netherlands Metabolomics Centre, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. ^[4] Sino-Dutch Center for Preventive and Personalized Medicine, P.O. Box 360, 3700 AJ, Zeist, The Netherlands. ^[5] TNO, Netherlands Organization for Applied Scientific Research, Microbiology and Systems Biology, P.O. Box 360, 3700 AJ, Zeist, The Netherlands. ^[6] Discovery Sciences, Janssen R&D, Turnhoutseweg 30, 2340, Beerse, Belgium. ^[7] Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02.127, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. ^[8]

关键词 LC-MS/MS Metabolomics Oxidized lipids Urine β-glucuronidase