Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.-论文-万方医学网

第一作者： Philipp S,Hoppe

第一单位： Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.;Research Unit Stem Cell Dynamics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

作者： Philipp S,Hoppe ^[1] ; Michael,Schwarzfischer ^[2] ; Dirk,Loeffler ^[1] ; Konstantinos D,Kokkaliaris ^[1] ; Oliver,Hilsenbeck ^[3] ; Nadine,Moritz ^[4] ; Max,Endele ^[1] ; Adam,Filipczyk ^[4] ; Adriana,Gambardella ^[5] ; Nouraiz,Ahmed ^[6] ; Martin,Etzrodt ^[6] ; Daniel L,Coutu ^[6] ; Michael A,Rieger ^[4] ; Carsten,Marr ^[2] ; Michael K,Strasser ^[2] ; Bernhard,Schauberger ^[4] ; Ingo,Burtscher ^[7] ; Olga,Ermakova ^[8] ; Antje,Bürger ^[9] ; Heiko,Lickert ^[10] ; Claus,Nerlov ^[11] ; Fabian J,Theis ^[12] ; Timm,Schroeder ^[1]

作者单位： Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.;Research Unit Stem Cell Dynamics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. ^[1] Institute of Computational Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany. ^[2] Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.;Research Unit Stem Cell Dynamics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.;Institute of Computational Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany. ^[3] Research Unit Stem Cell Dynamics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. ^[4] MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. ^[5] Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland. ^[6] Institute of Diabetes and Regeneration Research, Institute of Stem Cell Research, Helmholtz Zentrum München, Business Campus Garching, 85748 Garching, Germany. ^[7] Istituto di Biologia Cellulare e Neurobiologia, CNR, 00015 Monterotondo, Italy. ^[8] Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. ^[9] Institute of Diabetes and Regeneration Research, Institute of Stem Cell Research, Helmholtz Zentrum München, Business Campus Garching, 85748 Garching, Germany.;Beta Cell Biology, Medical Faculty, Technical University Munich (TUM), 80333 Munich, Germany. ^[10] MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.;EMBL Mouse Biology Unit, 00015 Monterotondo, Italy. ^[11] Institute of Computational Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.;Department of Mathematics, Technical University Munich, 85748 Garching, Germany. ^[12]

医学主题词动物(Animals);细胞分化(Cell Differentiation);细胞谱系(Cell Lineage);红细胞(Erythrocytes);反馈, 生理(Feedback, Physiological);女(雌)性(Female);GATA1转录因子(GATA1 Transcription Factor);基因, 报告(Genes, Reporter);粒细胞(Granulocytes);血细胞生成(Hematopoiesis);造血干细胞(Hematopoietic Stem Cells);男(雄)性(Male);巨核细胞(Megakaryocytes);小鼠(Mice);模型, 生物学(Models, Biological);单核细胞(Monocytes);髓系细胞(Myeloid Cells);原癌基因蛋白质类(Proto-Oncogene Proteins);结果可重复性(Reproducibility of Results);单细胞分析(Single-Cell Analysis);随机过程(Stochastic Processes);反式激活因子类(Trans-Activators)

DOI 10.1038/nature18320

PMID 27411635

发布时间 2025-05-29

基金项目

G0701761/MRC_/Medical Research Council/United Kingdom G0900892/MRC_/Medical Research Council/United Kingdom MC_UU_12009/7/MRC_/Medical Research Council/United Kingdom

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Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Nature

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Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Nature

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Nature

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