An adaptive design for updating the threshold value of a continuous biomarker.

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作者： Amy V,Spencer ^[1] ; Chris,Harbron ^[2] ; Adrian,Mander ^[3] ; James,Wason ^[3] ; Ian,Peers ^[4]

作者单位： AstraZeneca, Global Medicines Development, Biometrics and Information Sciences, Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K.. amy.v.spencer86@gmail.com. ^[1] Roche Pharmaceuticals, 6 Falcon Way, Welwyn Garden City, AL7 1TW, U.K. ^[2] MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Forvie Site, Robinson Way, Cambridge, CB2 0SR, U.K. ^[3] AstraZeneca, Global Medicines Development, Biometrics and Information Sciences, Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K. ^[4]

关键词 Bayesian prediction adaptive design biomarker-guided trial enrichment threshold determination

主题词贝叶斯定理(Bayes Theorem);临床试验(主题)(Clinical Trials as Topic);人类(Humans);病人遴选(Patient Selection);研究设计(Research Design)

DOI 10.1002/sim.7042

PMID 27417407

发布时间 2021-01-09

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