N7-platinated ribonucleotides are not incorporated by RNA polymerases. New perspectives for a rational design of platinum antitumor drugs.

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作者： Michele,Benedetti ^[1] ; Alessandro,Romano ^[2] ; Federica,De Castro ^[3] ; Chiara R,Girelli ^[3] ; Daniela,Antonucci ^[3] ; Danilo,Migoni ^[3] ; Tiziano,Verri ^[3] ; Francesco P,Fanizzi ^[4]

作者单位： Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, Italy. Electronic address: michele.benedetti@unisalento.it. ^[1] Neuropathology Unit, Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132 Milan, Italy. ^[2] Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, Italy. ^[3] Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Monteroni, I-73100 Lecce, Italy. Electronic address: fp.fanizzi@unisalento.it. ^[4]

关键词 Antitumor drug Cisplatin DNA Metalated purine RNA

主题词抗肿瘤药(Antineoplastic Agents);DNA, 细菌(DNA, Bacterial);指导DNA的RNA聚合酶类(DNA-Directed RNA Polymerases);药物设计(Drug Design);大肠杆菌(Escherichia coli);大肠杆菌蛋白质类(Escherichia coli Proteins);乳糖操纵子(Lac Operon);有机铂化合物(Organoplatinum Compounds);RNA, 细菌(RNA, Bacterial);核糖核苷酸类(Ribonucleotides);病毒蛋白质类(Viral Proteins)

DOI 10.1016/j.jinorgbio.2016.07.004

PMID 27421694

发布时间 2020-12-09

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Journal of inorganic biochemistry

2016年163卷

143-146页

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N7-platinated ribonucleotides are not incorporated by RNA polymerases. New perspectives for a rational design of platinum antitumor drugs.

Journal of inorganic biochemistry

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Journal of inorganic biochemistry

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N7-platinated ribonucleotides are not incorporated by RNA polymerases. New perspectives for a rational design of platinum antitumor drugs.

Journal of inorganic biochemistry

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Journal of inorganic biochemistry

相关期刊

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