Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial.

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作者： Thomas P,Hellyer ^[1] ; Niall H,Anderson ^[2] ; Jennie,Parker ^[3] ; Paul,Dark ^[4] ; Tina,Van Den Broeck ^[5] ; Suveer,Singh ^[6] ; Ronan,McMullan ^[7] ; Ashley M,Agus ^[8] ; Lydia M,Emerson ^[9] ; Bronagh,Blackwood ^[9] ; Savita,Gossain ^[10] ; Tim S,Walsh ^[11] ; Gavin D,Perkins ^[12] ; Andrew,Conway Morris ^[13] ; Daniel F,McAuley ^[8] ; A John,Simpson ^[9]

作者单位： Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. t.p.hellyer@ncl.ac.uk. ^[1] Centre for Population Health Sciences, University of Edinburgh, Medical School, Edinburgh, UK. ^[2] Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK. ^[3] Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Sciences Centre & Intensive Care Unit, Salford Royal NHS Foundation Trust, Greater Manchester, UK. ^[4] Becton Dickinson Biosciences, Erembodegem, Aalst, Belgium. ^[5] Intensive Care Unit, Chelsea and Westminster Hospital, Imperial College London, London, UK. ^[6] Department of Medical Microbiology, Kelvin Building, The Royal Hospitals, Belfast, UK. ^[7] Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Belfast, UK. ^[8] Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK. ^[9] Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham, UK. ^[10] MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. ^[11] University of Warwick and Heart of England NHS Foundation Trust, Coventry, UK. ^[12] Division of Anaesthesia, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK. ^[13] Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, UK. ^[14] Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. ^[15]

关键词 Antibiotic stewardship Biomarker Randomised controlled trial Ventilator-acquired pneumonia