首页> Cancer immunology, immunotherapy : CII> Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice.

Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice.

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第一作者： Abderraouf,Selmi

第一单位： TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.;Research Center for Immunotherapy (FZI), University Medical Center of Johannes Gutenberg University, Mainz, Germany.

作者： Abderraouf,Selmi ^[1] ; Fulvia,Vascotto ^[2] ; Kordula,Kautz-Neu ^[3] ; Özlem,Türeci ^[4] ; Ugur,Sahin ^[5] ; Esther,von Stebut ^[3] ; Mustafa,Diken ^[6] ; Sebastian,Kreiter ^[7]

作者单位： TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.;Research Center for Immunotherapy (FZI), University Medical Center of Johannes Gutenberg University, Mainz, Germany. ^[1] TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany. ^[2] Department of Dermatology, University Medical Center of Johannes Gutenberg University, Mainz, Germany. ^[3] Cluster for Individualized Immune Intervention (CI3), Mainz, Germany. ^[4] TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.;Research Center for Immunotherapy (FZI), University Medical Center of Johannes Gutenberg University, Mainz, Germany.;BioNTech RNA Pharmaceuticals GmbH, Mainz, Germany. ^[5] TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany. Mustafa.Diken@TrOn-Mainz.de.;BioNTech RNA Pharmaceuticals GmbH, Mainz, Germany. Mustafa.Diken@TrOn-Mainz.de. ^[6] TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany. Sebastian.Kreiter@TrOn-Mainz.de.;BioNTech RNA Pharmaceuticals GmbH, Mainz, Germany. Sebastian.Kreiter@TrOn-Mainz.de. ^[7]

关键词 Cancer immunotherapy Dermal dendritic cell Intradermal vaccination Macropinocytosis Naked RNA RNA vaccine