Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease.-论文-万方医学网

作者： Pia,Runeberg-Roos ^[1] ; Elisa,Piccinini ^[2] ; Anna-Maija,Penttinen ^[2] ; Kert,Mätlik ^[2] ; Hanna,Heikkinen ^[2] ; Satu,Kuure ^[2] ; Maxim M,Bespalov ^[2] ; Johan,Peränen ^[2] ; Enrique,Garea-Rodríguez ^[3] ; Eberhard,Fuchs ^[4] ; Mikko,Airavaara ^[2] ; Nisse,Kalkkinen ^[2] ; Richard,Penn ^[5] ; Mart,Saarma ^[2]

作者单位： Institute of Biotechnology, University of Helsinki, PB 56 (Viikinkaari 5D), FIN-00014, Finland. Electronic address: pia.runeberg@helsinki.fi. ^[1] Institute of Biotechnology, University of Helsinki, PB 56 (Viikinkaari 5D), FIN-00014, Finland. ^[2] Department of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany. ^[3] German Primate Center, Göttingen, Germany. ^[4] CNS Therapeutics Inc., 332 Minnesota Street, Ste W1750, St. Paul, MN 55101, USA. ^[5]

主题词苯丙胺(Amphetamine);动物(Animals);CHO细胞(CHO Cells);仓鼠属(Cricetulus);疾病模型, 动物(Disease Models, Animal);药物设计(Drug Design);遗传变异(Genetic Variation);人类(Humans);成束猴(Macaca fascicularis);男(雄)性(Male);模型, 分子(Models, Molecular);Neurturin神经营养因子(Neurturin);羟多巴胺(Oxidopamine);帕金森病(Parkinson Disease);原癌基因蛋白质c-ret(Proto-Oncogene Proteins c-ret);大鼠(Rats);大鼠, Wistar(Rats, Wistar);刻板行为(Stereotyped Behavior);抗交感神经药(Sympatholytics);酪氨酸单氧化酶(Tyrosine 3-Monooxygenase)

DOI 10.1016/j.nbd.2016.07.008

PMID 27425888

发布时间 2018-02-09

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Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease.

Neurobiology of disease

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Neurobiology of disease

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Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease.

Neurobiology of disease

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Neurobiology of disease

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