Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.

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作者： Hwei-Ming,Peng ^[1] ; Sang-Choul,Im ^[1] ; Naw May,Pearl ^[1] ; Adina F,Turcu ; Juilee,Rege ; Lucy,Waskell ; Richard J,Auchus

作者单位： Department of Anesthesiology, University of Michigan and the VA Medical Center , 2215 Fuller Road, Building 31, Room 225, Ann Arbor, Michigan 48105, United States. ^[1]

主题词氨基酸取代(Amino Acid Substitution);雄激素类(Androgens);雄甾烯类(Androstenes);催化域(Catalytic Domain);细胞色素b5类(Cytochromes b5);酶激活(Enzyme Activation);酶抑制剂(Enzyme Inhibitors);人类(Humans);模型, 分子(Models, Molecular);诱变, 定点(Mutagenesis, Site-Directed);突变蛋白质类(Mutant Proteins);NADP(NADP);NADPH高铁血红素蛋白还原酶(NADPH-Ferrihemoprotein Reductase);蛋白质构象(Protein Conformation);重组蛋白质类(Recombinant Proteins);类固醇17-α-羟化酶(Steroid 17-alpha-Hydroxylase)

DOI 10.1021/acs.biochem.6b00532

PMID 27426448

发布时间 2024-06-10

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Biochemistry

2016年55卷31期

4356-65页

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Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.

Biochemistry

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Biochemistry

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Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.

Biochemistry

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Biochemistry

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