Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation.

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作者： Jun,Han ^[1] ; Hai,Zhang ^[1] ; Sheng,Wang ^[2] ; Jun,Zhou ^[1] ; Yi,Luo ^[1] ; Li-Hong,Long ^[1] ; Zhuang-Li,Hu ^[3] ; Fang,Wang ^[4] ; Jian-Guo,Chen ^[5] ; Peng-Fei,Wu ^[1]

作者单位： Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China. ^[1] School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. ^[2] Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, 430030, Hubei, China. ^[3] The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, 430030, Hubei, China. ^[4] Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. ^[5] Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China. wupengfeipharm@foxmail.com. ^[6] Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, 430030, Hubei, China. wupengfeipharm@foxmail.com. ^[7] The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, 430030, Hubei, China. wupengfeipharm@foxmail.com. ^[8] Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. wupengfeipharm@foxmail.com. ^[9]

关键词 DHHC (Asp-His-His-Cys) 3 GluA1 GluA2 Mercaptan Palmitoylation α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)