首页> The New England journal of medicine> Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

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第一作者： Jesse M,Zaretsky

第一单位： From the University of California, Los Angeles (UCLA) (J.M.Z., A.G.-D., D.S.S., H.E.-O., W.H., S.H.-L., D.Y.T., G.A.-R., S.S., L.B., J.S., B.H.M., B.C., K.R., I.P.S., P.J.S., C.P.-S., G.C., E.S., X.K., J.P., B.B.-M., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.), and Jonsson Comprehensive Cancer Center (B.C., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.) - both in Los Angeles; and the Division of Immunology, Netherlands Cancer Institute, Amsterdam (R.M., T.N.M.S.).

作者： Jesse M,Zaretsky ^[1] ; Angel,Garcia-Diaz ^[1] ; Daniel S,Shin ^[1] ; Helena,Escuin-Ordinas ^[1] ; Willy,Hugo ^[1] ; Siwen,Hu-Lieskovan ^[1] ; Davis Y,Torrejon ^[1] ; Gabriel,Abril-Rodriguez ^[1] ; Salemiz,Sandoval ^[1] ; Lucas,Barthly ^[1] ; Justin,Saco ^[1] ; Blanca,Homet Moreno ^[1] ; Riccardo,Mezzadra ^[1] ; Bartosz,Chmielowski ^[1] ; Kathleen,Ruchalski ^[1] ; I Peter,Shintaku ^[1] ; Phillip J,Sanchez ^[1] ; Cristina,Puig-Saus ^[1] ; Grace,Cherry ^[1] ; Elizabeth,Seja ^[1] ; Xiangju,Kong ^[1] ; Jia,Pang ^[1] ; Beata,Berent-Maoz ^[1] ; Begoña,Comin-Anduix ^[1] ; Thomas G,Graeber ^[1] ; Paul C,Tumeh ^[1] ; Ton N M,Schumacher ^[1] ; Roger S,Lo ^[1] ; Antoni,Ribas ^[1]

作者单位： From the University of California, Los Angeles (UCLA) (J.M.Z., A.G.-D., D.S.S., H.E.-O., W.H., S.H.-L., D.Y.T., G.A.-R., S.S., L.B., J.S., B.H.M., B.C., K.R., I.P.S., P.J.S., C.P.-S., G.C., E.S., X.K., J.P., B.B.-M., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.), and Jonsson Comprehensive Cancer Center (B.C., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.) - both in Los Angeles; and the Division of Immunology, Netherlands Cancer Institute, Amsterdam (R.M., T.N.M.S.). ^[1]

医学主题词抗肿瘤药(Antineoplastic Agents);活组织检查(Biopsy);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因, MHCⅠ类(Genes, MHC Class I);人类(Humans);免疫疗法(Immunotherapy);干扰素γ(Interferon-gamma);Janus激酶1(Janus Kinase 1);Janus激酶2(Janus Kinase 2);黑色素瘤(Melanoma);突变(Mutation);复发(Recurrence);序列分析, DNA(Sequence Analysis, DNA);信号传导(Signal Transduction);β2微球蛋白(beta 2-Microglobulin)

DOI 10.1056/NEJMoa1604958

PMID 27433843

发布时间 2022-04-10

基金项目

GM08042/GM/NIGMS NIH HHS/United States T32 GM008042/GM/NIGMS NIH HHS/United States 5T32CA009120-39/CA/NCI NIH HHS/United States UL1 TR000124/TR/NCATS NIH HHS/United States R35 CA197633/CA/NCI NIH HHS/United States U54 CA199090/CA/NCI NIH HHS/United States P30 CA016042/CA/NCI NIH HHS/United States T32 CA009120/CA/NCI NIH HHS/United States R01 CA170689/CA/NCI NIH HHS/United States 5T32CA009297-30/CA/NCI NIH HHS/United States T32 CA009297/CA/NCI NIH HHS/United States P01 CA168585/CA/NCI NIH HHS/United States 5T32AR058921-05/AR/NIAMS NIH HHS/United States UL1 TR001881/TR/NCATS NIH HHS/United States 1U54 CA199090/CA/NCI NIH HHS/United States T32 AR058921/AR/NIAMS NIH HHS/United States

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