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Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

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第一作者： Adele,Mucci

第一单位： Research Group Reprogramming and Gene Therapy, Cluster of Excellence REBIRTH, Hannover Medical School, 30625 Hannover, Germany; Junior Research Group Translational Hematology of Congenital Diseases, Cluster of Excellence REBIRTH, Hannover Medical School, Carl-Neuberg-Street 1, 30625 Hannover, Germany; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.

作者： Adele,Mucci ^[1] ; Jessica,Kunkiel ^[2] ; Takuji,Suzuki ^[3] ; Sebastian,Brennig ^[1] ; Silke,Glage ^[4] ; Mark P,Kühnel ^[5] ; Mania,Ackermann ^[1] ; Christine,Happle ^[6] ; Alexandra,Kuhn ^[2] ; Axel,Schambach ^[7] ; Bruce C,Trapnell ^[3] ; Gesine,Hansen ^[6] ; Thomas,Moritz ^[2] ; Nico,Lachmann ^[8]

作者单位： Research Group Reprogramming and Gene Therapy, Cluster of Excellence REBIRTH, Hannover Medical School, 30625 Hannover, Germany; Junior Research Group Translational Hematology of Congenital Diseases, Cluster of Excellence REBIRTH, Hannover Medical School, Carl-Neuberg-Street 1, 30625 Hannover, Germany; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany. ^[1] Research Group Reprogramming and Gene Therapy, Cluster of Excellence REBIRTH, Hannover Medical School, 30625 Hannover, Germany; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany. ^[2] Translational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[3] Institute of Laboratory Animal Science and Central Animal Facility, Hannover Medical School, 30625 Hannover, Germany. ^[4] Department of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany. ^[5] Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany. ^[6] Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. ^[7] Junior Research Group Translational Hematology of Congenital Diseases, Cluster of Excellence REBIRTH, Hannover Medical School, Carl-Neuberg-Street 1, 30625 Hannover, Germany; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany. Electronic address: lachmann.nico@mh-hannover.de. ^[8]

关键词 PAP disease modeling hematopoiesis iPSC macrophages