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首页> European journal of pharmacology> Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity.

Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity.

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作者： Michelle S,Antunes ^[1] ; Cristiano R,Jesse ^[2] ; Jossana Rodrigues,Ruff ^[1] ; Dieniffer,de Oliveira Espinosa ^[1] ; Nathalie Savedra,Gomes ^[1] ; Elza Eliza Tenório,Altvater ^[1] ; Franciele,Donato ^[1] ; Renata,Giacomeli ^[1] ; Silvana Peterini,Boeira ^[1]

作者单位： Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, RS, Brazil. ^[1] Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, RS, Brazil. Electronic address: cristianoricardojesse@yahoo.com.br. ^[2]

关键词 Cytokines Hesperidin Neurotrophins Olfactory bulbectomy

主题词乙酰胆碱酯酶(Acetylcholinesterase);动物(Animals);行为, 动物(Behavior, Animal);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);认知(Cognition);细胞因子类(Cytokines);抑郁(Depression);橙皮苷(Hesperidin);海马(Hippocampus);男(雄)性(Male);迷宫学习(Maze Learning);小鼠(Mice);嗅球(Olfactory Bulb)

DOI 10.1016/j.ejphar.2016.07.042

PMID 27460180

发布时间 2017-08-06

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European journal of pharmacology

411-420页

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European journal of pharmacology

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