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Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.

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第一作者： Alessandro T,Caputo

第一单位： Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom;

作者： Alessandro T,Caputo ^[1] ; Dominic S,Alonzi ^[1] ; Lucia,Marti ^[2] ; Ida-Barbara,Reca ^[2] ; J L,Kiappes ^[1] ; Weston B,Struwe ^[1] ; Alice,Cross ^[1] ; Souradeep,Basu ^[1] ; Edward D,Lowe ^[1] ; Benoit,Darlot ^[3] ; Angelo,Santino ^[2] ; Pietro,Roversi ^[4] ; Nicole,Zitzmann ^[4]

作者单位： Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; ^[1] Institute of Sciences of Food Production, Consiglio Nazionale delle Ricerche Unit of Lecce, 73100 Lecce, Italy; ^[2] Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; Ecole Nationale Supérieure de Chimie de Montpellier, 34296 Montpellier Cedex 5, France. ^[3] Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; pietro.roversi@bioch.ox.ac.uk nicole.zitzmann@bioch.ox.ac.uk. ^[4]

关键词 ER α-glucosidase II broad-spectrum antiviral eukaryotic secretion glycoprotein folding iminosugar