Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.

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第一作者： Andrew M,Cobb

第一单位： The James Black Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.

作者： Andrew M,Cobb ^[1] ; Delphine,Larrieu ^[2] ; Derek T,Warren ^[1] ; Yiwen,Liu ^[1] ; Sonal,Srivastava ^[1] ; Andrew J O,Smith ^[3] ; Richard P,Bowater ^[3] ; Stephen P,Jackson ^[2] ; Catherine M,Shanahan ^[1]

作者单位： The James Black Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK. ^[1] Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK. ^[2] School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK. ^[3]

关键词 53BP1 NUP153 Ran gradient cytoplasmic-nuclear trafficking prelamin A vascular disease

DOI 10.1111/acel.12506

PMID 27464478

发布时间 2024-02-10

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