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mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos.

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第一作者： Stephen W,Eichhorn

第一单位： Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, United States.;Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.

作者： Stephen W,Eichhorn ^[1] ; Alexander O,Subtelny ^[2] ; Iva,Kronja ^[3] ; Jamie C,Kwasnieski ^[1] ; Terry L,Orr-Weaver ^[3] ; David P,Bartel ^[1]

作者单位： Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, United States.;Department of Biology, Massachusetts Institute of Technology, Cambridge, United States. ^[1] Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, United States.;Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.;Harvard-MIT Division of Health Sciences and Technology, Cambridge, United States. ^[2] Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.;Whitehead Institute for Biomedical Research, Cambridge, United States. ^[3]

关键词 D. melanogaster Drosophila embryogenesis Drosophila oogenesis PAL-seq chromosomes developmental biology genes posttranscriptional gene regulation ribosome footprint profiling stem cells wispy

医学主题词动物(Animals);果蝇属(Drosophila);基因表达调控(Gene Expression Regulation);卵母细胞(Oocytes);蛋白质生物合成(Protein Biosynthesis);RNA, 信使(RNA, Messenger)

DOI 10.7554/eLife.16955

PMID 27474798

发布时间 2018-11-13

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