Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.

导出原文传递

翻译打印收藏纠错

第一作者： Rajeev S,Bhide

第一单位： Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. Electronic address: rajeev.bhide@bms.com.

作者： Rajeev S,Bhide ^[1] ; James,Neels ^[2] ; Lan-Ying,Qin ^[2] ; Zheming,Ruan ^[2] ; Sylwia,Stachura ^[2] ; Carolyn,Weigelt ^[3] ; John S,Sack ^[3] ; Kevin,Stefanski ^[4] ; Xiaomei,Gu ^[4] ; Jenny H,Xie ^[5] ; Christine B,Goldstine ^[5] ; Stacey,Skala ^[5] ; Donna L,Pedicord ^[5] ; Stefan,Ruepp ^[4] ; T G Murali,Dhar ^[2] ; Percy H,Carter ^[2] ; Luisa M,Salter-Cid ^[5] ; Michael A,Poss ^[2] ; Paul,Davies ^[5]

作者单位： Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. Electronic address: rajeev.bhide@bms.com. ^[1] Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. ^[2] Molecular structure and design, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. ^[3] PCO discovery, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. ^[4] Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. ^[5]

关键词 PI3Kδ Phosphatidylinositol-3 kinases Pyrrolo[2,1-f][1,2,4]triazin-4-amine Rheumatoid arthritis