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首页> Colloids and surfaces. B, Biointerfaces> Effective transdermal delivery of methotrexate through nanostructured lipid carriers in an experimentally induced arthritis model.

Effective transdermal delivery of methotrexate through nanostructured lipid carriers in an experimentally induced arthritis model.

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作者： Neeraj K,Garg ^[1] ; Bhupinder,Singh ^[2] ; Rajeev K,Tyagi ^[3] ; Gajanand,Sharma ^[1] ; Om Prakash,Katare ^[4]

作者单位： Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India. ^[1] Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India; UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160 014, India. ^[2] Department of Periodontics, College of Dental Medicine Georgia Regents University, 1120, 15th Street, Augusta, GA 30912, USA; Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad 382 481 Gujarat, India. ^[3] Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India. Electronic address: drkatare@yahoo.com. ^[4]

关键词 Chemical enhancer Gelucire(?) 50/13 Methotrexate Phospolipon S 100 Rheumatoid arthritis Transcutol(?)P Transdermal delivery

主题词投药, 皮肤(Administration, Cutaneous);动物(Animals);关节炎, 实验性(Arthritis, Experimental);细胞存活(Cell Survival);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);炎症(Inflammation);脂类(Lipids);甲氨蝶呤(Methotrexate);纳米结构(Nanostructures);大鼠(Rats);大鼠, Wistar(Rats, Wistar)

DOI 10.1016/j.colsurfb.2016.07.046

PMID 27478959

发布时间 2017-09-04

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Colloids and surfaces. B, Biointerfaces

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