Repetitive Dosing of Fumed Silica Leads to Profibrogenic Effects through Unique Structure-Activity Relationships and Biopersistence in the Lung.

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作者： Bingbing,Sun ^[1] ; Xiang,Wang ^[2] ; Yu-Pei,Liao ^[1] ; Zhaoxia,Ji ^[3] ; Chong Hyun,Chang ; Suman,Pokhrel ; Justine,Ku ; Xiangsheng,Liu ; Meiying,Wang ; Darren R,Dunphy ; Ruibin,Li ; Huan,Meng ; Lutz,Mädler ; C Jeffrey,Brinker ; André E,Nel ; Tian,Xia

作者单位： Foundation Institute of Materials Science (IWT), Department of Production Engineering, University of Bremen , 28359 Bremen, Germany. ^[1] School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University , Suzhou 215123, China. ^[2] Self-Assembled Materials Department, Sandia National Laboratories , P.O. Box 5800 MS1349, Albuquerque, New Mexico 87185, United States. ^[3]

关键词 biopersistence dissolution fumed silica lung fibrosis metal doping

主题词动物(Animals);炎性体(Inflammasomes);肺(Lung);小鼠(Mice);纳米管, 碳(Nanotubes, Carbon);二氧化硅(Silicon Dioxide);构效关系(Structure-Activity Relationship)

DOI 10.1021/acsnano.6b04143

PMID 27483033

发布时间 2018-12-02

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