Identification of Covalent Binding Sites Targeting Cysteines Based on Computational Approaches.

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第一作者： Yanmin,Zhang

第一单位： Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University , 639 Longmian Avenue, Nanjing 211198, China.

作者： Yanmin,Zhang ^[1] ; Danfeng,Zhang ^[2] ; Haozhong,Tian ^[2] ; Yu,Jiao ^[2] ; Zhihao,Shi ^[2] ; Ting,Ran ^[1] ; Haichun,Liu ^[1] ; Shuai,Lu ^[1] ; Anyang,Xu ^[2] ; Xin,Qiao ^[1] ; Jing,Pan ^[1] ; Lingfeng,Yin ^[1] ; Weineng,Zhou ^[1] ; Tao,Lu ^[1] ; Yadong,Chen ^[1]

作者单位： Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University , 639 Longmian Avenue, Nanjing 211198, China. ^[1] State Key Laboratory of Natural Medicines, China Pharmaceutical University , 24 Tongjiaxiang, Nanjing 210009, China. ^[2]

关键词 covalent binding sites cysteines fragment probing irreversible inhibitors

主题词结合部位(Binding Sites);半胱氨酸(Cysteine);人类(Humans);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白质结构, 二级(Protein Structure, Secondary);构效关系(Structure-Activity Relationship)

DOI 10.1021/acs.molpharmaceut.6b00302

PMID 27483186

发布时间 2018-12-02

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