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Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors.

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第一作者： Haiyong,Jia

第一单位： Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.

作者： Haiyong,Jia ^[1] ; Fuxiang,Bai ^[2] ; Na,Liu ^[1] ; Xiaohong,Liang ^[2] ; Peng,Zhan ^[1] ; Chunhong,Ma ^[2] ; Xuemei,Jiang ^[3] ; Xinyong,Liu ^[4]

作者单位： Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China. ^[1] Department of Immunology, Key Laboratory for Experimental, Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Medicine, Jinan, 250012, Shandong Province, PR China. ^[2] Department of Hepatic Diseases, Jinan Infectious Disease Hospital, Jingshi Road, 173, 250021, Jinan, Shandong, PR China. ^[3] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address: xinyongl@sdu.edu.cn. ^[4]

关键词 Bioisosterism HBV Hybrid pharmacophore-based Non-nucleoside SAR