Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.

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第一作者： Norikatsu,Miyoshi

第一单位： Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129;

作者： Norikatsu,Miyoshi ^[1] ; Jente M,Stel ^[2] ; Keiko,Shioda ^[1] ; Na,Qu ^[1] ; Junko,Odajima ^[1] ; Shino,Mitsunaga ^[1] ; Xiangfan,Zhang ^[3] ; Makoto,Nagano ^[3] ; Konrad,Hochedlinger ^[4] ; Kurt J,Isselbacher ^[5] ; Toshi,Shioda ^[5]

作者单位： Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129; ^[1] Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129; Institute for Environmental Studies Vrije Universiteit, Amsterdam 1081 HV, The Netherlands; ^[2] Department of Obstetrics and Gynecology, McGill University and Research Institute of McGill University Health Centre, Montreal, QC, Canada H4A 3J1; ^[3] Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138. ^[4] Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129; kisselbacher@mgh.harvard.edu tshioda@mgh.harvard.edu. ^[5]

关键词 PGCLC epigenetic reprogramming epimutation genetic imprinting