Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk.
作者:
Daniele,Campa [1]
;
Manuela,Pastore [2]
;
Manuel,Gentiluomo [1]
;
Renata,Talar-Wojnarowska [2]
;
Juozas,Kupcinskas [1]
;
Ewa,Malecka-Panas [2]
;
John P,Neoptolemos [3]
;
Willem,Niesen [4]
;
Pavel,Vodicka [3]
;
Gianfranco,Delle Fave [5]
;
H Bas,Bueno-de-Mesquita [6]
;
Maria,Gazouli [7]
;
Paola,Pacetti [8]
;
Milena,Di Leo [9]
;
Hidemi,Ito [10]
;
Harald,Klüter [11]
;
Pavel,Soucek [12]
;
Vincenzo,Corbo [13]
;
Kenji,Yamao [14]
;
Satoyo,Hosono [15]
;
Rudolf,Kaaks [16]
;
Yogesh,Vashist [17]
;
Domenica,Gioffreda [18]
;
Oliver,Strobel [19]
;
Yasuhiro,Shimizu [20]
;
Frederike,Dijk [21]
;
Angelo,Andriulli [16]
;
Audrius,Ivanauskas [22]
;
Peter,Bugert [23]
;
Francesca,Tavano [24]
;
Ludmila,Vodickova [6]
;
Carlo Federico,Zambon [25]
;
Martin,Lovecek [26]
;
Stefano,Landi [24]
;
Timothy J,Key [4]
;
Ugo,Boggi [17]
;
Raffaele,Pezzilli [24]
;
Krzysztof,Jamroziak [8]
;
Beatrice,Mohelnikova-Duchonova [27]
;
Andrea,Mambrini [28]
;
Franco,Bambi [29]
;
Olivier,Busch [1]
;
Valerio,Pazienza [30]
;
Roberto,Valente [31]
;
George E,Theodoropoulos [32]
;
Thilo,Hackert [33]
;
Gabriele,Capurso [18]
;
Giulia Martina,Cavestro [34]
;
Claudio,Pasquali [14]
;
Daniela,Basso [35]
;
Cosimo,Sperti [36]
;
Keitaro,Matsuo [24]
;
Markus,Büchler [9]
;
Kay-Tee,Khaw [37]
;
Jakob,Izbicki [6]
;
Eithne,Costello [9]
;
Verena,Katzke [15]
;
Christoph,Michalski [38]
;
Anna,Stepien [39]
;
Cosmeri,Rizzato [38]
;
Federico,Canzian [40]
作者单位:
Department of Biology, University of Pisa, Pisa, Italy.
[1]
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[2]
Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
[3]
Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
[4]
Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom.
[5]
Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
[6]
Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic.
[7]
Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic.
[8]
Digestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University of Rome, Rome, Italy.
[9]
Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
[10]
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom.
[11]
Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[12]
Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
[13]
Oncological Department Massa Carrara Azienda USL Toscana Nord Ovest, Carrara, Italy.
[14]
Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
[15]
Division Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
[16]
Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service Baden-Württemberg - Hessen gGmbH, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
[17]
Laboratory of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic.
[18]
Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
[19]
ARC-Net Research Centre, and Department of Diagnostics and Public Health University and Hospital Trust of Verona, Verona, Italy.
[20]
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan.
[21]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[22]
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[23]
Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
[24]
Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
[25]
Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands.
[26]
Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic.
[27]
Department of Medicine - DIMED, University of Padova, Padova, Italy.
[28]
Department of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
[29]
Epidemiology Unit Nuffield Department of Population Health University of Oxford, Oxford, UK.
[30]
Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy.
[31]
Pancreas Unit, Department of Digestive System, Dant'Orsola-Malpighi Hospital, Bologna, Italy.
[32]
Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
[33]
Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
[34]
Blood Transfusion Service, Azienda Ospedaliero Universitaria Meyer, Florence, Italy.
[35]
Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
[36]
Colorectal Unit, First Department of Propaedeutic Surgery, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
[37]
Department of Surgery, Oncology and Gastroenterology-DiSCOG, University of Padova, Padova, Italy.
[38]
Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy.
[39]
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
[40]
Clinical Gerontology Unit, Addenbrooke’s Hospital, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
[41]
Laboratory of Clinical, Transplant Immunology and Genetics, Copernicus Memorial Hospital, Lodz, Poland.
[42]
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
[43]
主题词
等位基因(Alleles);结合部位(Binding Sites);癌, 胰腺管(Carcinoma, Pancreatic Ductal);病例对照研究(Case-Control Studies);周期素依赖激酶抑制剂p15(Cyclin-Dependent Kinase Inhibitor p15);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);周期素依赖激酶抑制剂p18(Cyclin-Dependent Kinase Inhibitor p18);DNA甲基化(DNA Methylation);疾病恶化(Disease Progression);疾病遗传易感性(Genetic Predisposition to Disease);基因型(Genotype);生殖细胞系突变(Germ-Line Mutation);人类(Humans);国际合作(International Cooperation);日本(Japan);比值比(Odds Ratio);胰腺肿瘤(Pancreatic Neoplasms);多态性, 单核苷酸(Polymorphism, Single Nucleotide);预后(Prognosis);回顾性研究(Retrospective Studies)
DOI
10.18632/oncotarget.10935
PMID
27486979
发布时间
2024-02-10
- 浏览54

Oncotarget
Oncotarget
57011-57020页
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