Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.

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作者： Riina,Kaukonen ^[1] ; Anja,Mai ^[1] ; Maria,Georgiadou ^[1] ; Markku,Saari ^[1] ; Nicola,De Franceschi ^[1] ; Timo,Betz ^[2] ; Harri,Sihto ^[3] ; Sami,Ventelä ^[1] ; Laura,Elo ^[4] ; Eija,Jokitalo ^[1] ; Jukka,Westermarck ^[5] ; Pirkko-Liisa,Kellokumpu-Lehtinen ^[6] ; Heikki,Joensuu ^[1] ; Reidar,Grenman ^[7] ; Johanna,Ivaska ^[3]

作者单位： Centre for Biotechnology, University of Turku, 20520 Turku, Finland. ^[1] Institute of Cell Biology, Center for Molecular Biology of Inflammation, 48149 Muenster, Germany. ^[2] Laboratory of Molecular Oncology, Translational Cancer Biology Program, University of Helsinki, 00290 Helsinki, Finland. ^[3] Department of Otorhinolaryngology, Head and Neck Surgery, Turku University and Turku University Hospital, 20521 Turku, Finland. ^[4] Department of Mathematics and Statistics, University of Turku, 20520, Turku, Finland. ^[5] Institute of Biotechnology, Electron Microscopy Unit University of Helsinki, 00014 Helsinki, Finland. ^[6] Department of Oncology, Tampere University Hospital, 36280 Tampere, Finland. ^[7] Department of Oncology, Helsinki University Central Hospital, 00029 Helsinki, Finland. ^[8] Department of Biochemistry and Food Chemistry, University of Turku, 20520 Turku, Finland. ^[9]

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);鸡(Chickens);细胞外基质(Extracellular Matrix);成纤维细胞(Fibroblasts);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);含Jumonji结构域组蛋白脱甲基酶类(Jumonji Domain-Containing Histone Demethylases);动力传导, 细胞(Mechanotransduction, Cellular);肿瘤(Neoplasms);间质细胞(Stromal Cells);反式激活因子类(Trans-Activators);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic)

DOI 10.1038/ncomms12237

PMID 27488962

发布时间 2024-03-25

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Nature communications

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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.

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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.

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