首页> Proceedings of the National Academy of Sciences of the United States of America> Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).

Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).

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第一作者： Zhe Li,Salie

第一单位： C. S. Bond Life Sciences Center, Department of Biochemistry, University of Missouri, Columbia, MO 65211;

作者： Zhe Li,Salie ^[1] ; Karen A,Kirby ^[2] ; Eleftherios,Michailidis ^[2] ; Bruno,Marchand ^[2] ; Kamalendra,Singh ^[2] ; Lisa C,Rohan ^[3] ; Eiichi N,Kodama ^[4] ; Hiroaki,Mitsuya ^[5] ; Michael A,Parniak ^[6] ; Stefan G,Sarafianos ^[7]

作者单位： C. S. Bond Life Sciences Center, Department of Biochemistry, University of Missouri, Columbia, MO 65211; ^[1] C. S. Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65211; ^[2] Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213; ^[3] Division of Infectious Diseases, Tohoku University and Tohoku Medical Megabank Organization, Sendai 980-8575, Japan; ^[4] Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Department of Infectious Diseases, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan; Department of Hematology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan; Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; ^[5] Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219. ^[6] C. S. Bond Life Sciences Center, Department of Biochemistry, University of Missouri, Columbia, MO 65211; C. S. Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65211; sarafianoss@missouri.edu. ^[7]

关键词 EFdA HIV-1 reverse transcriptase NRTIs X-ray crystallography inhibitors

医学主题词抗HIV药(Anti-HIV Agents);催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);脱氧腺苷类(Deoxyadenosines);酶稳定性(Enzyme Stability);HIV逆转录酶(HIV Reverse Transcriptase);逆转录酶抑制剂(Reverse Transcriptase Inhibitors)

DOI 10.1073/pnas.1605223113

PMID 27489345

发布时间 2022-03-16

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