B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation.

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作者： Christopher,Tay ^[1] ; Yu-Han,Liu ^[2] ; Hamid,Hosseini ^[1] ; Peter,Kanellakis ^[2] ; Anh,Cao ^[1] ; Karlheinz,Peter ^[3] ; Peter,Tipping ^[4] ; Alex,Bobik ^[2] ; Ban-Hock,Toh ^[4] ; Tin,Kyaw ^[5]

作者单位： Vascular Biology and Atherosclerosis Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, Victoria 3004, Australia Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences. Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia. ^[1] Vascular Biology and Atherosclerosis Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, Victoria 3004, Australia. ^[2] Atherothrombosis and Vascular Biology Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, Victoria 3004, Australia. ^[3] Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences. Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia. ^[4] Vascular Biology and Atherosclerosis Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, Melbourne, Victoria 3004, Australia Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences. Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia tinsoe.kyaw@bakeridi.edu.au. ^[5]

关键词 Apoptosis Atherosclerosis B2 cells Inflammation TNF-α