In silico Exploration of the Conformational Universe of GPCRs.

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第一作者： Ismael,Rodríguez-Espigares

第一单位： Pharmacoinformatics group, Research Programme on Biomedical Informatics (GRIB), Universitat Pompeu Fabra (UPF)-Hospital del Mar Medical Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, 08003, Barcelona, Spain.

作者： Ismael,Rodríguez-Espigares ^[1] ; Agnieszka A,Kaczor ^[2] ; Jana,Selent ^[3]

作者单位： Pharmacoinformatics group, Research Programme on Biomedical Informatics (GRIB), Universitat Pompeu Fabra (UPF)-Hospital del Mar Medical Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, 08003, Barcelona, Spain. ^[1] Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division for Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20059, Lublin, Poland. ^[2] School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. ^[3] Pharmacoinformatics group, Research Programme on Biomedical Informatics (GRIB), Universitat Pompeu Fabra (UPF)-Hospital del Mar Medical Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, 08003, Barcelona, Spain. jana.selent@upf.edu. ^[4]

关键词 Conformation analysis Drug design Membrane proteins Molecular dynamics Signal transduction

主题词人类(Humans);分子动力学模拟(Molecular Dynamics Simulation);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction)

DOI 10.1002/minf.201600012

PMID 27492237

发布时间 2018-09-26

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准确一般字义偏差语意偏离译文作用小提交