Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.

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第一作者： Olivér,Éliás

第一单位： Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary. Electronic address: elias@richter.hu.

作者： Olivér,Éliás ^[1] ; Zoltán,Kovács ^[2] ; Gábor,Wágner ^[2] ; Zsolt,Némethy ^[2] ; Ákos,Tarcsay ^[2] ; István,Greiner ^[2]

作者单位： Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary. Electronic address: elias@richter.hu. ^[1] Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary. ^[2]

关键词 Designed multiple ligands Dopamine D(2)/D(3) receptors Histamine H(3) receptors Multitarget directed ligands Polypharmacology Serotonin 5-HT(6) receptors

主题词人类(Humans);吲哚类(Indoles);配体(Ligands);蛋白质结合(Protein Binding);受体, 多巴胺D2(Receptors, Dopamine D2);受体, 多巴胺D3(Receptors, Dopamine D3);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);受体, 组胺H3(Receptors, Histamine H3);受体, 血清素(Receptors, Serotonin);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2016.07.055

PMID 27496213

发布时间 2018-10-24

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Bioorganic & medicinal chemistry letters

2016年26卷17期

4211-5页

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Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.

Bioorganic & medicinal chemistry letters

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Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

相关期刊

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