Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses.

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作者： Pim,Schipper ^[1] ; Koen,van der Maaden ^[2] ; Stefan,Romeijn ^[3] ; Cees,Oomens ^[4] ; Gideon,Kersten ^[5] ; Wim,Jiskoot ^[6] ; Joke,Bouwstra ^[7]

作者单位： Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address: p.schipper@lacdr.leidenuniv.nl. ^[1] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address: k.van.der.maaden@lacdr.leidenuniv.nl. ^[2] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address: romeijn@lacdr.leidenuniv.nl. ^[3] Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address: c.w.j.oomens@tue.nl. ^[4] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Intravacc (Institute for Translational Vaccinology), Bilthoven, The Netherlands. Electronic address: gideon.kersten@intravacc.nl. ^[5] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address: w.jiskoot@lacdr.leidenuniv.nl. ^[6] Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address: bouwstra@lacdr.leidenuniv.nl. ^[7]

关键词 Adjuvant Dose-sparing Fractional dose Hollow microneedles Inactivated polio vaccine Intradermal immunization Poliomyelitis