Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing.

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作者： Manjunatha R,Benakanakere ^[1] ; Livia S,Finoti ^[1] ; Urara,Tanaka ^[2] ; Gregory R,Grant ^[1] ; Raquel M,Scarel-Caminaga ^[3] ; Denis F,Kinane ^[4]

作者单位： Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Department of Oral Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP- Univ Estadual Paulista, SP, Brazil. ^[2] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, PA, USA. ^[3] Department of Morphology, School of Dentistry at Araraquara, UNESP- Univ Estadual Paulista, SP, Brazil. ^[4] Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[5]

主题词基因组, 人(Genome, Human);HEK293细胞(HEK293 Cells);人类(Humans);白细胞介素8(Interleukin-8);中性白细胞(Neutrophils);聚肌胞苷酸(Poly I-C);多态性, 单核苷酸(Polymorphism, Single Nucleotide);蛋白质生物合成(Protein Biosynthesis);转录, 遗传(Transcription, Genetic)

DOI 10.1038/srep31180

PMID 27499075

发布时间 2019-08-16

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Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing.

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Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing.

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