Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes.

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作者： Daniel C,Millard ^[1] ; Christopher J,Strock ^[2] ; Coby B,Carlson ^[3] ; Natsuyo,Aoyama ^[3] ; Krisztina,Juhasz ^[4] ; Tom A,Goetze ^[5] ; Sonja,Stoelzle-Feix ^[4] ; Nadine,Becker ^[4] ; Niels,Fertig ^[4] ; Craig T,January ^[4] ; Blake D,Anson ^[6] ; James D,Ross ^[3]

作者单位： *Axion BioSystems, Inc, Atlanta, Georgia dmillard@axion-biosystems.com. ^[1] Cyprotex, Watertown, Massachusetts. ^[2] Cellular Dynamics International, a Fujifilm Company, Madison, Wisconsin. ^[3] Nanion Technologies GmbH, Munich, Germany. ^[4] Technische Universitat Munchen, Munich, Germany. ^[5] School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin. ^[6] *Axion BioSystems, Inc, Atlanta, Georgia. ^[7]

关键词 cardiac electrophysiology cardiomyocyte drug interactions safety stem cell

主题词胺碘酮(Amiodarone);药物相互作用(Drug Interactions);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);肌细胞, 心脏(Myocytes, Cardiac)

DOI 10.1093/toxsci/kfw153

PMID 27503387

发布时间 2018-12-02

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