首页> Drug metabolism and disposition: the biological fate of chemicals> In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.

In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.

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第一作者： Johan,Monbaliu

第一单位： Janssen Research & Development, Preclinical Project Development (J.M.), Bioanalysis (H.St.), Pharmacokinetics, Dynamics and Metabolism (J.S, I.W.), and Clinical Pharmacology, (H.Sm.), Beerse, Belgium; Janssen Research & Development, Clinical Pharmacology (M.G., A.B.) and Biometrics and Reporting (J.J.), Raritan, New Jersey; Janssen Research & Development, Pharmacokinetics, Dynamics and Metabolism (C.S.), Spring House, Pennsylvania; Janssen Research & Development, Clinical Pharmacology (C.C.), Titusville, New Jersey.

作者： Johan,Monbaliu ^[1] ; Martha,Gonzalez ^[1] ; Apexa,Bernard ^[1] ; James,Jiao ^[1] ; Carlo,Sensenhauser ^[1] ; Jan,Snoeys ^[1] ; Hans,Stieltjes ^[1] ; Inneke,Wynant ^[1] ; Johan W,Smit ^[1] ; Caly,Chien ^[2]

作者单位： Janssen Research & Development, Preclinical Project Development (J.M.), Bioanalysis (H.St.), Pharmacokinetics, Dynamics and Metabolism (J.S, I.W.), and Clinical Pharmacology, (H.Sm.), Beerse, Belgium; Janssen Research & Development, Clinical Pharmacology (M.G., A.B.) and Biometrics and Reporting (J.J.), Raritan, New Jersey; Janssen Research & Development, Pharmacokinetics, Dynamics and Metabolism (C.S.), Spring House, Pennsylvania; Janssen Research & Development, Clinical Pharmacology (C.C.), Titusville, New Jersey. ^[1] Janssen Research & Development, Preclinical Project Development (J.M.), Bioanalysis (H.St.), Pharmacokinetics, Dynamics and Metabolism (J.S, I.W.), and Clinical Pharmacology, (H.Sm.), Beerse, Belgium; Janssen Research & Development, Clinical Pharmacology (M.G., A.B.) and Biometrics and Reporting (J.J.), Raritan, New Jersey; Janssen Research & Development, Pharmacokinetics, Dynamics and Metabolism (C.S.), Spring House, Pennsylvania; Janssen Research & Development, Clinical Pharmacology (C.C.), Titusville, New Jersey CCHIEN@its.jnj.com. ^[2]

医学主题词人类(Humans);微粒体, 肝(Microsomes, Liver)

DOI 10.1124/dmd.116.070672

PMID 27504016

发布时间 2025-02-12

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