Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy.

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第一作者： Frieder,Bauss

第一单位： Roche Pharma Research & Early Development (pRED), Discovery Oncology, Innovation Center Munich, Roche Diagnostics GmbH Penzberg, Nonnenwald 2, D-82377 Penzberg, Germany.

作者： Frieder,Bauss ^[1] ; Martin,Lechmann ^[2] ; Ben-Fillippo,Krippendorff ^[3] ; Roland,Staack ^[2] ; Frank,Herting ^[1] ; Matthias,Festag ^[3] ; Sabine,Imhof-Jung ^[4] ; Friederike,Hesse ^[4] ; Marc,Pompiati ^[4] ; Gwendlyn,Kollmorgen ^[1] ; Rita,da Silva Mateus Seidl ^[1] ; Birgit,Bossenmaier ^[1] ; Wilma,Lau ^[4] ; Christian,Schantz ^[4] ; Jan O,Stracke ^[5] ; Ulrich,Brinkmann ^[4] ; Masanori,Onda ^[6] ; Ira,Pastan ^[6] ; Klaus,Bosslet ^[1] ; Gerhard,Niederfellner ^[7]

作者单位： Roche Pharma Research & Early Development (pRED), Discovery Oncology, Innovation Center Munich, Roche Diagnostics GmbH Penzberg, Nonnenwald 2, D-82377 Penzberg, Germany. ^[1] Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Innovation Center Munich, Roche Diagnostics GmbH Penzberg, Nonnenwald 2, D-82377 Penzberg, Germany. ^[2] Roche pRED Innovation Center Basel, Pharmaceutical Sciences, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, CH-4070 Basel, Switzerland. ^[3] Roche Pharma Research & Early Development (pRED), Large Molecule Research, Innovation Center Munich, Roche Diagnostics GmbH Penzberg, Nonnenwald 2, D-82377 Penzberg, Germany. ^[4] Roche Pharma Research & Early Development (pRED), Large Molecule Research, Innovation Center Munich, Roche Diagnostics GmbH Penzberg, Nonnenwald 2, D-82377 Penzberg, Germany; Pharmaceutical Development & Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland. ^[5] Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. ^[6] Roche Pharma Research & Early Development (pRED), Discovery Oncology, Innovation Center Munich, Roche Diagnostics GmbH Penzberg, Nonnenwald 2, D-82377 Penzberg, Germany. Electronic address: gerhard.niederfellner@roche.com. ^[7]

关键词 De-immunization Immunotoxin Lung cancer Patient-derived xenografts Pharmacokinetics Targeted therapy