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首页> European journal of medicinal chemistry> Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.

Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.

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作者： Anastassia L,Kantsadi ^[1] ; Éva,Bokor ^[2] ; Sándor,Kun ^[2] ; George A,Stravodimos ^[1] ; Demetra S M,Chatzileontiadou ^[1] ; Demetres D,Leonidas ^[3] ; Éva,Juhász-Tóth ^[2] ; Andrea,Szakács ^[2] ; Gyula,Batta ^[2] ; Tibor,Docsa ^[4] ; Pál,Gergely ^[4] ; László,Somsák ^[5]

作者单位： Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str. 41221, Larissa, Greece. ^[1] Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary. ^[2] Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str. 41221, Larissa, Greece. Electronic address: ddleonidas@bio.uth.gr. ^[3] Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary. ^[4] Department of Organic Chemistry, University of Debrecen, POB 400, H-4002, Debrecen, Hungary. Electronic address: somsak.laszlo@science.unideb.hu. ^[5]

关键词 C-Glucopyranosyl derivative Diabetes type 2 Glycogen phosphorylase inhibitor Imidazole Indole Pyrrole

主题词动物(Animals);结晶学, X线(Crystallography, X-Ray);酶抑制剂(Enzyme Inhibitors);糖原磷酸化酶(Glycogen Phosphorylase);人类(Humans);咪唑类(Imidazoles);动力学(Kinetics);肝(Liver);模型, 分子(Models, Molecular);蛋白质构象(Protein Conformation);吡咯类(Pyrroles);兔(Rabbits);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2016.06.049

PMID 27522507

发布时间 2017-08-11

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European journal of medicinal chemistry

737-745页

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