换一批
换一批Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
作者：
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);Caco-2细胞(Caco-2 Cells);细胞周期蛋白质类(Cell Cycle Proteins);结晶学, X线(Crystallography, X-Ray);狗(Dogs);女(雌)性(Female);肝细胞(Hepatocytes);杂环化合物, 2环(Heterocyclic Compounds, 2-Ring);人类(Humans);小鼠, SCID(Mice, SCID);肿瘤移植(Neoplasm Transplantation);核蛋白质类(Nuclear Proteins);哌嗪类(Piperazines);蛋白质构象(Protein Conformation);吡唑类(Pyrazoles);哒嗪类(Pyridazines);大鼠(Rats);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship);转录因子(Transcription Factors)
DOI
10.1021/acs.jmedchem.6b00070
PMID
27528113
发布时间
2021-12-04
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