The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease.

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作者： Samantha,Cialfi ^[1] ; Loredana,Le Pera ^[2] ; Carlo,De Blasio ^[1] ; Germano,Mariano ^[1] ; Rocco,Palermo ^[2] ; Azzurra,Zonfrilli ^[1] ; Daniela,Uccelletti ^[3] ; Claudio,Palleschi ^[3] ; Gianfranco,Biolcati ^[4] ; Luca,Barbieri ^[4] ; Isabella,Screpanti ^[1] ; Claudio,Talora ^[5]

作者单位： Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. ^[1] Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy. ^[2] Department of Biology and Biotechnology "C. Darwin"; Sapienza University of Rome, Rome, Italy. ^[3] Porphyria Center, San Gallicano Institute IRCCS, Rome, Italy. ^[4] Istituto Pasteur Italia, Fondazione Cenci-Bolognetti, Italy. ^[5]

主题词钙转运ATP酶类(Calcium-Transporting ATPases);细胞分化(Cell Differentiation);DNA损伤(DNA Damage);表皮(Epidermis);基因表达(Gene Expression);内环境稳定(Homeostasis);人类(Humans);角蛋白细胞(Keratinocytes);氧化性应激(Oxidative Stress);天疱疮, 良性家族性(Pemphigus, Benign Familial);受体, Notch1(Receptor, Notch1)

DOI 10.1038/srep31567

PMID 27528123

发布时间 2024-05-29

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The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease.

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The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease.

Scientific reports

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