Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.

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第一作者： Kathryn E,Hacker

第一单位： From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Lineberger Comprehensive Cancer Center, and.

作者： Kathryn E,Hacker ^[1] ; Catherine C,Fahey ^[1] ; Stephen A,Shinsky ^[2] ; Yun-Chen J,Chiang ^[3] ; Julia V,DiFiore ^[4] ; Deepak Kumar,Jha ^[2] ; Andy H,Vo ^[5] ; Jordan A,Shavit ^[5] ; Ian J,Davis ^[6] ; Brian D,Strahl ^[7] ; W Kimryn,Rathmell ^[8]

作者单位： From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Lineberger Comprehensive Cancer Center, and. ^[1] the Lineberger Comprehensive Cancer Center, and the Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599. ^[2] the Lineberger Comprehensive Cancer Center, and. ^[3] From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599. ^[4] the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109. ^[5] From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Lineberger Comprehensive Cancer Center, and the Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27514, and. ^[6] From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Lineberger Comprehensive Cancer Center, and the Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, brian_strahl@med.unc.edu. ^[7] From the Department of Genetics, Curriculum in Genetics and Molecular Biology, the Lineberger Comprehensive Cancer Center, and the Division of Hematology and Oncology, Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232 kimryn.rathmell@vanderbilt.edu. ^[8]

关键词 H3K36 SETD2 Set2 cancer chromatin enzyme histone methylation mutant