Enlarged leukocyte referent libraries can explain additional variance in blood-based epigenome-wide association studies.

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第一作者： Stephanie,Kim

第一单位： Department of Epidemiology, Brown University School of Public Health, Providence, RI 02912, USA.;Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.

作者： Stephanie,Kim ^[1] ; Melissa,Eliot ^[2] ; Devin C,Koestler ^[3] ; Eugene A,Houseman ^[4] ; James G,Wetmur ^[5] ; John K,Wiencke ^[6] ; Karl T,Kelsey ^[7]

作者单位： Department of Epidemiology, Brown University School of Public Health, Providence, RI 02912, USA.;Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA. ^[1] Department of Epidemiology, Brown University School of Public Health, Providence, RI 02912, USA. ^[2] Department of Biostatistics, University of Kansas Medical Center, Kansas City, KA 66160, USA. ^[3] Oregon State University College of Public Health & Human Sciences, Corvallis, OR 97331, USA. ^[4] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[5] Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94158, USA. ^[6] Department of Epidemiology, Brown University School of Public Health, Providence, RI 02912, USA.;Department of Laboratory Medicine & Pathology, Brown University, Providence, RI 02912, USA. ^[7]

关键词 450K methylation library DNA methylation aging arthritis cell mixture deconvolution cellular heterogeneity confounding differentially methylated regions epigenome-wide association study inflammation lymphocytes