Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies.

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作者： Robert W,Cross ^[1] ; Chad E,Mire ^[2] ; Luis M,Branco ^[1] ; Joan B,Geisbert ^[2] ; Megan M,Rowland ^[3] ; Megan L,Heinrich ^[1] ; Augustine,Goba ^[2] ; Mambu,Momoh ^[3] ; Donald S,Grant ^[3] ; Mohamed,Fullah ^[4] ; Sheik Humarr,Khan ^[5] ; James E,Robinson ^[4] ; Thomas W,Geisbert ^[5] ; Robert F,Garry ^[6]

作者单位： Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Texas, USA. ^[1] Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA. ^[2] Zalgen Labs, LLC, Germantown, MD. ^[3] Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone. ^[4] Ministry of Health and Sanitation, Freetown, Sierra Leone. ^[5] Polytechnic College, Kenema Sierra Leone. ^[6] Sections of Infectious Disease, Departments of Pediatrics and Internal Medicine, School of Medicine, Tulane University, New Orleans, LA. ^[7] Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, USA. ^[8]

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);豚鼠(Guinea Pigs);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);拉沙热(Lassa Fever);拉沙病毒(Lassa virus);中和试验(Neutralization Tests)

DOI 10.1016/j.antiviral.2016.08.012

PMID 27531367

发布时间 2018-11-13

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Antiviral research

2016年133卷

218-222页

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Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies.

Antiviral research

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Antiviral research

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Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies.

Antiviral research

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Antiviral research

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