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首页> Journal of autoimmunity> Medullary thymic epithelial cells and CD8α<sup>+</sup> dendritic cells coordinately regulate central tolerance but CD8α<sup>+</sup> cells are dispensable for thymic regulatory T cell production.

Medullary thymic epithelial cells and CD8α<sup>+</sup> dendritic cells coordinately regulate central tolerance but CD8α<sup>+</sup> cells are dispensable for thymic regulatory T cell production.

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作者： Olivier,Herbin ^[1] ; Anthony J,Bonito ^[1] ; Seihwan,Jeong ^[1] ; Erica G,Weinstein ^[1] ; Adeeb H,Rahman ^[2] ; Huabao,Xiong ^[1] ; Miriam,Merad ^[2] ; Konstantina,Alexandropoulos ^[3]

作者单位： Department of Medicine/Clinical Immunology, The Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[1] Department of Medicine/Clinical Immunology, The Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute/Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[2] Department of Medicine/Clinical Immunology, The Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: k.alexandropoulos@mssm.edu. ^[3]

关键词 Autoimmunity Dendritic cells Medullary thymic epithelial cells Regulatory T cells

主题词动物(Animals);抗原呈递细胞(Antigen-Presenting Cells);自身免疫(Autoimmunity);树突细胞(Dendritic Cells);上皮细胞(Epithelial Cells);流式细胞术(Flow Cytometry);免疫耐受(Immune Tolerance);淋巴细胞去除术(Lymphocyte Depletion);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);模型, 免疫学(Models, Immunological);受体, 免疫(Receptors, Immunologic);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);胸腺(Thymus Gland)

DOI 10.1016/j.jaut.2016.08.002

PMID 27543048

发布时间 2018-11-13

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Journal of autoimmunity

141-149页

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