Delivery of an inactivated avian influenza virus vaccine adjuvanted with poly(D,L-lactic-co-glycolic acid) encapsulated CpG ODN induces protective immune responses in chickens.

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作者： Shirene M,Singh ^[1] ; Tamiru N,Alkie ^[2] ; Éva,Nagy ^[3] ; Raveendra R,Kulkarni ^[4] ; Douglas C,Hodgins ^[5] ; Shayan,Sharif ^[6]

作者单位： Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: shirene@uoguelph.ca. ^[1] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: talkie@uoguelph.ca. ^[2] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: enagy@uoguelph.ca. ^[3] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: kulkarnr@uoguelph.ca. ^[4] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: dhodgins@uoguelph.ca. ^[5] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: shayan@uoguelph.ca. ^[6]

关键词 Avian influenza virus Chickens CpG ODN Delivery system Immune response Nanoparticle Poly(D,L-lactic-co-glycolic acid)